IMMUNOCAP ISAC PDF

J Allergy Clin Immunol. Epub May ImmunoCAP assays: Pros and cons in allergology. Electronic address: marianne. Allergen-specific IgE measurements and the clinical history are the cornerstones of allergy diagnosis. During the past decades, both characterization and standardization of allergen extracts and assay technology have improved.

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J Allergy Clin Immunol. Epub May ImmunoCAP assays: Pros and cons in allergology. Electronic address: marianne. Allergen-specific IgE measurements and the clinical history are the cornerstones of allergy diagnosis. During the past decades, both characterization and standardization of allergen extracts and assay technology have improved.

The major benefit of ImmunoCAP is the obtained quantified allergen-specific IgE antibody level and the lack of interference from allergen-specific IgG antibodies. However, ImmunoCAP allergen extracts are limited to the composition of the extract. The introduction of allergen molecules has had a major effect on analytic specificity and allergy diagnosis. The shortcomings are its semiquantitative measurements, lower linear range, and cost per assay.

With respect to assay performance, ImmunoCAP allergen extracts are good screening tools, but allergen molecules dissect the IgE response on a molecular level and put allergy research on the map of precision medicine.

Published by Elsevier Inc. All rights reserved.

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